Archive for the Cholesterol

Statins are America’s best selling drugs as of 11/07–the lastest stat I can find. Lipitor sold $9 Billion worth and Zocor $4.7 Billion. 12 Million Americans take one and more are being fed into the pipeline all the time. According to an ABC news online article from Dec. 2009,” The joke in the world of heart disease is that “they should put statins in the water,” but to a U.S. Food and Drug Administration advisory panel that has recommended giving statins to “healthy” people, it’s no joke. The panel voted 12 to four with one abstention to recommend that the potent statin Crestor (rosuvastatin) be approved to prevent heart attacks in people who have no history of heart disease and don’t fit the traditional profile of an “at risk” population.”

The results of the trail of about 17,000 people from 25 countries is this, of the half that got Crestor, levels of mortality and morbidity were reduced vs the half that got a placebo.By how much? 70 or so people out of 8901. The reduction in events was tied to reduction of CRP– or C-reactive protein which is a marker of inflammation and an important test for anyone with a history of heart disease or any symptoms of heart problems. Did I mention that this trial was sponsored–that means paid for–by Crestor? And that some cardiologists pointed to the increase in diabetes in the subjects who got the drug vs the placebo group? That last finding was not mentioned by the people who published the findings.

This was not meant to be a diatribe against yet another fatal flaw in the current illness care system but I had to point out some startling and (should be) scary statistics. A statin drug could be coming your way, ill health or no. My point in this post is to tell you about the importance of taking the supplement CoQ10 if you are on a statin–or considering one. (It’s important for cardiovascular health and a supp I recommend even for those of us not on statins but it’s imperative for statin users as you’ll see.)

CoQ10 is the raw material needed for energy production within the cells. (That’s the reader’s digest version) It is also a scavenger of the free radicals produced by this process. Statin drugs not only suppress cholesterol production  they suppress production of CoQ10. Muscles are the biggest consumers of energy–the heart is the muscle that uses most because it never rests. Can you see the problem here? Less CoQ10 means less energy being made for the heart which is supposed to benefit from the use of a statin drug.

So what really occurs with too little CoQ10 on board? Let me quote one of the best integrative cardiologists I know. Dr. Steven Sinatra reported in his 2/09 newsletter, “The cascade effect that results from statin therapy goes something like this: lower CoQ10 levels lead to decreased ATP production, (energy production) which leads to diastolic dysfunction of the left ventricle, which leads to heart failure.”

That’s heart failure, the very thing the statin is supposed to be protecting you from. In countries like Japan, Germany and others in the EU, statin drugs come with a warning that it is recommended that you supplement with CoQ10 if you are taking this drug. Doctors prescribe it when people are in their offices. Clearly if other countries not so tied to their pharmaceutical behemoths can warn patients of a necessary, safe, and easy to use adjunct to the statin therapy, our government has that option.

Low CoQ10 also leads to muscle pain and weakness and fuzzy thinking. I don’t know about you but at this age I don’t need any help in that area. If you are on a statin, please do not stop it abruptly! If you want to add CoQ10 the best form is ubiquinone according to Dr. Sinatra. That’s because it’s converted, in the body, into ubiquinol, the antioxidant form of CoQ10. And the form you’ll see most often.) You can get a hydrosoluble product or a gel cap type. If you are on a statin, many of the docs I follow suggest 200 mgs per day in divided doses. You can talk to your MD about this but many will be unaware of the statin/CoQ10 connection. Drs. Sinatra, Julian Whitaker, Jim Roberts, and many other integrative cardiologists can be found online with more information.

One last quote, from the Journal of the American College of Cardiology, a bastion of all things conservative and Big Pharma focused. They reported a study that proved that higher levels of CoQ10 was related to longer life for heart failure patients. It wasn’t a very well publicized finding. I wonder why?

In the second in a series of 4 articles on the truth about cholesterol–why you want it and how lowering it by all means is not healthy–begins by looking at the different “parts” if you will of the cholesterol molecules.
We most commonly talk about and test for LDL or “bad” cholesterol and HDL or “good.” The L in those two acronyms stands for lipoprotein and is basically a coating around the cholesterol that allows it to be water soluble and therefore move around and work in our blood.
LDL cholesterol-low density lipoproteins carry cholesterol to the cells for repair work as well as the many other important functions they have. HDL, high density lipoproteins carry cholesterol away from the cells and arterial walls and back to the liver to be used or disposed of.

Here’s the sixty-four millions dollar question: how can one part of cholesterol be good and the other bad just because one travels in one direction and the other moves in another?

Here’s a little history:
In 1948 The Framingham Study was begun. It was designed to study heart disease and followed 5,000 men and women to determine some common traits among those who succumbed to the disease.
Here’s an important point, this study was observational, not a double blind, placebo controlled testing environment. It simply tracked people and checked in with them over the years to see what they were eating, their lifestyle habits, and it checked blood levels and health markers looking for commonalities in those that ended up with heart disease.
In 1961 cholesterol was “discovered’ and although the Framingham study had to date uncovered important lifestyle factors that promoted heart disease, like smoking, once cholesterol was “outed” the medical world locked on to it as a way to prevent heart disease. It may have made sense initially but the thousands of tests and research papers that were produced to prove it was the culprit have never been able to do so.

Enter Ancel Keys, by all reports a blustery, self important scientist from the U of Minnesota. According to Dr. Dwight Lundel “Keys’ theory, one he actively promoted to an increasingly health conscious public, was that an association existed between the rate of cardiovascular disease of a population, serum cholesterol and their intake of saturated fats.”

Keys was able to convince the US government that dietary fat equaled increased rates of heart disease and death but the proof is in the health statistics.
Consumption of dietary fat decreased from the 1960’s to the 1990’s but the rate of heart disease did not and instead, the incidence of obesity and Type II diabetes soared. As the fat got stripped from our diet–as did the Yumm factor–heart disease rates soared and so did rates of depression and anti-depression drug sales.

Here’s where it gets interesting. The people in the Framingham study ate what they wanted and the amount of saturated fats varied widely. No matter how they twisted their findings they could not prove a cause and effect relationship between the fat participants ate and the cholesterol floating in their blood.

At the end of the study–22 years after they began to compile research–the scientists concluded:

“There is, in short, no suggestion of any relation between diet and

the subsequent development of chronic heart disease in the study group.”

I’m going to end here today. Tomorrow I’ll explain a little bit about how low-fat-diets-save-lives became the nation’s health dogma. As you might expect is has something to do with politics, lobbyists and Big Pharma.

I’ll also reveal what aspects of cholesterol do relate to food and what foods are dangerous ones, the ones to avoid.

What if all you’ve been told about lowering cholesterol to prevent disease was just not true?

For the longest time I’ve been coming upon studies that buck the conventional–and very profitable-wisdom that cholesterol causes heart disease. The research I’ve been doing further disproves the link between what we eat and our cholesterol levels.

Now before your inner critic commandeers the floor, read on and I’ll do my best to lay a foundation of science to back up my title.

Cholesterol is manufactured by the liver and is essential for life. It is not, as so many people think, “fat in the blood.” It’s a waxy substance, soapy to the touch, and only 7% of it is found there. The other 93%, according to Dr. Owen Fanorow, “is located in every cell of the body, where its unique waxy, soapy consistency provides the cell membranes with their structural integrity and regulates the flow of nutrients into and waste products out of the cells.”

Here are a few of the roles cholesterol plays:

• Cholesterol is a precursor of vitamin D in the skin. When exposed to sunlight, this precursor molecule is converted to its active form for use in the body.
• Cholesterol is the main component of bile acids, which aid in the digestion of foods, particularly fatty foods. Without cholesterol we could not absorb the essential fat-soluble vitamins A, D, E and K from the food we eat.
• Cholesterol is necessary for normal growth and development of the brain and nervous system . Cholesterol coats the nerves and makes the transmission of nerve impulses possible.
• Cholesterol gives skin its ability to shed water.
• Cholesterol is important for normal growth and repair of tissues since every cell membrane and the organelles (the tiny structures inside the cells that carry out specific functions) within the cells are rich in cholesterol. For this reason newborn animals feed on milk or other cholesterol-rich foods, such as the yolks of eggs, which are there to provide food for the developing bird or chick embryos.

Let’s stop there though the list goes on and on. I have one more really important aspect of cholesterol’s importance to introduce now as it’s flu–infectious bug– season.

According to Dr. Uffe Ravnskov, in his book Fat and Cholesterol Are Good For You!, “Did you know that high cholesterol protects you against infectious diseases?” He cites many studies but this one stood out to me. (And understand that this is the Reader’s Digest version)

David Jacobs, Ph.D, Mayo Professor of Public Health followed more than 100,000 healthy individuals in the San Francisco Bay area for 15 years. He found that those who had low cholesterol to start the study had been admitted to the hospital more times for infectious diseases.

It is a known and accepted fact that bacteria and other such bugs may play an important role in heart failure. Without going in to a long explanation of why and how that works, suffice to say that researchers both here and abroad discovered that not only was mortality highest when immune function was not optimal but mortality was higher in the patients with the lowest cholesterol!

Maybe all this lowering of LDL cholesterol isn’t the healthy prescription it’s cracked up to be?

Tomorrow I’ll continue laying a foundation with more on the function of cholesterol in the body and whether or not your food choices cause your numbers to increase or not.  If you don’t want to wait for me to lay it all out here over the next few days I’d suggest you take a look at Dr. Dwight Lundell’s book, The Cholesterol Lie. Dr. Lundell was a heart surgeon, has performed over 5000 bypass surgeries, and felt he had to tell the world what he learned after seeing so many damaged hearts. His mission is to keep people off the operating table and his book will tell you how and why what we all now believe as gospel hasn’t got a prayer in terms of keeping us healthy.