Statins are America’s best selling drugs as of 11/07–the lastest stat I can find. Lipitor sold $9 Billion worth and Zocor $4.7 Billion. 12 Million Americans take one and more are being fed into the pipeline all the time. According to an ABC news online article from Dec. 2009,” The joke in the world of heart disease is that “they should put statins in the water,” but to a U.S. Food and Drug Administration advisory panel that has recommended giving statins to “healthy” people, it’s no joke. The panel voted 12 to four with one abstention to recommend that the potent statin Crestor (rosuvastatin) be approved to prevent heart attacks in people who have no history of heart disease and don’t fit the traditional profile of an “at risk” population.”
The results of the trail of about 17,000 people from 25 countries is this, of the half that got Crestor, levels of mortality and morbidity were reduced vs the half that got a placebo.By how much? 70 or so people out of 8901. The reduction in events was tied to reduction of CRP– or C-reactive protein which is a marker of inflammation and an important test for anyone with a history of heart disease or any symptoms of heart problems. Did I mention that this trial was sponsored–that means paid for–by Crestor? And that some cardiologists pointed to the increase in diabetes in the subjects who got the drug vs the placebo group? That last finding was not mentioned by the people who published the findings.
This was not meant to be a diatribe against yet another fatal flaw in the current illness care system but I had to point out some startling and (should be) scary statistics. A statin drug could be coming your way, ill health or no. My point in this post is to tell you about the importance of taking the supplement CoQ10 if you are on a statin–or considering one. (It’s important for cardiovascular health and a supp I recommend even for those of us not on statins but it’s imperative for statin users as you’ll see.)
CoQ10 is the raw material needed for energy production within the cells. (That’s the reader’s digest version) It is also a scavenger of the free radicals produced by this process. Statin drugs not only suppress cholesterol production they suppress production of CoQ10. Muscles are the biggest consumers of energy–the heart is the muscle that uses most because it never rests. Can you see the problem here? Less CoQ10 means less energy being made for the heart which is supposed to benefit from the use of a statin drug.
So what really occurs with too little CoQ10 on board? Let me quote one of the best integrative cardiologists I know. Dr. Steven Sinatra reported in his 2/09 newsletter, “The cascade effect that results from statin therapy goes something like this: lower CoQ10 levels lead to decreased ATP production, (energy production) which leads to diastolic dysfunction of the left ventricle, which leads to heart failure.”
That’s heart failure, the very thing the statin is supposed to be protecting you from. In countries like Japan, Germany and others in the EU, statin drugs come with a warning that it is recommended that you supplement with CoQ10 if you are taking this drug. Doctors prescribe it when people are in their offices. Clearly if other countries not so tied to their pharmaceutical behemoths can warn patients of a necessary, safe, and easy to use adjunct to the statin therapy, our government has that option.
Low CoQ10 also leads to muscle pain and weakness and fuzzy thinking. I don’t know about you but at this age I don’t need any help in that area. If you are on a statin, please do not stop it abruptly! If you want to add CoQ10 the best form is ubiquinone according to Dr. Sinatra. That’s because it’s converted, in the body, into ubiquinol, the antioxidant form of CoQ10. And the form you’ll see most often.) You can get a hydrosoluble product or a gel cap type. If you are on a statin, many of the docs I follow suggest 200 mgs per day in divided doses. You can talk to your MD about this but many will be unaware of the statin/CoQ10 connection. Drs. Sinatra, Julian Whitaker, Jim Roberts, and many other integrative cardiologists can be found online with more information.
One last quote, from the Journal of the American College of Cardiology, a bastion of all things conservative and Big Pharma focused. They reported a study that proved that higher levels of CoQ10 was related to longer life for heart failure patients. It wasn’t a very well publicized finding. I wonder why?
In the second in a series of 4 articles on the truth about cholesterol–why you want it and how lowering it by all means is not healthy–begins by looking at the different “parts” if you will of the cholesterol molecules.
We most commonly talk about and test for LDL or “bad” cholesterol and HDL or “good.” The L in those two acronyms stands for lipoprotein and is basically a coating around the cholesterol that allows it to be water soluble and therefore move around and work in our blood.
LDL cholesterol-low density lipoproteins carry cholesterol to the cells for repair work as well as the many other important functions they have. HDL, high density lipoproteins carry cholesterol away from the cells and arterial walls and back to the liver to be used or disposed of.
Here’s the sixty-four millions dollar question: how can one part of cholesterol be good and the other bad just because one travels in one direction and the other moves in another?
Here’s a little history:
In 1948 The Framingham Study was begun. It was designed to study heart disease and followed 5,000 men and women to determine some common traits among those who succumbed to the disease.
Here’s an important point, this study was observational, not a double blind, placebo controlled testing environment. It simply tracked people and checked in with them over the years to see what they were eating, their lifestyle habits, and it checked blood levels and health markers looking for commonalities in those that ended up with heart disease.
In 1961 cholesterol was “discovered’ and although the Framingham study had to date uncovered important lifestyle factors that promoted heart disease, like smoking, once cholesterol was “outed” the medical world locked on to it as a way to prevent heart disease. It may have made sense initially but the thousands of tests and research papers that were produced to prove it was the culprit have never been able to do so.
Enter Ancel Keys, by all reports a blustery, self important scientist from the U of Minnesota. According to Dr. Dwight Lundel “Keys’ theory, one he actively promoted to an increasingly health conscious public, was that an association existed between the rate of cardiovascular disease of a population, serum cholesterol and their intake of saturated fats.”
Keys was able to convince the US government that dietary fat equaled increased rates of heart disease and death but the proof is in the health statistics.
Consumption of dietary fat decreased from the 1960’s to the 1990’s but the rate of heart disease did not and instead, the incidence of obesity and Type II diabetes soared. As the fat got stripped from our diet–as did the Yumm factor–heart disease rates soared and so did rates of depression and anti-depression drug sales.
Here’s where it gets interesting. The people in the Framingham study ate what they wanted and the amount of saturated fats varied widely. No matter how they twisted their findings they could not prove a cause and effect relationship between the fat participants ate and the cholesterol floating in their blood.
At the end of the study–22 years after they began to compile research–the scientists concluded:
“There is, in short, no suggestion of any relation between diet and
the subsequent development of chronic heart disease in the study group.”
I’m going to end here today. Tomorrow I’ll explain a little bit about how low-fat-diets-save-lives became the nation’s health dogma. As you might expect is has something to do with politics, lobbyists and Big Pharma.
I’ll also reveal what aspects of cholesterol do relate to food and what foods are dangerous ones, the ones to avoid.
Yesterday’s issue of the New England Journal of Medicine reports that the very inexpensive nutritional supplement niacin worked better to clear arteries than the not so cheap and side effect rich drugs Zetia– a drug used in addition to a statin, and Vyotrin– a single pill which combines a statin with Zetia.
Much of the information I’m posting here comes from The Washington Post.
A recent trial gave 200 people one of the drugs or Niaspan, a form of the B vitamin Niacin. They were followed for 14 months. The results showed a decrease in artery clogging plaque in the niacin group but none in the pharmaceutical group. It’s plaque that causes problems and deaths not the cholesterol itself.
Vytorin and Zetia are among the most popular prescription drugs and were introduced with lots of fanfare and expensive advertising. Don’t worry though, Merck made their money back on those expenses. Last year, physicians in the United States wrote a total of more than 29 million prescriptions for them, and worldwide sales totaled $4.56 billion, according to Merck.
Critics of the study complained that it involved just 200 patients, was ended early, and examined what is known as a surrogate marker — the amount of plaque on artery walls — rather than evaluating the rate of heart attacks and stroke.
The study’s author, Allen J. Taylor of Walter Reed Army Medical Center and Washington Hospital Center, said the trial ended early because the results were quickly apparent. “It couldn’t be more clear,” Taylor said. “It would have been unreasonable to continue the experiment because the trial had met its objective — niacin is superior to ezetimibe.”
Because plaque can clog arteries and restrict blood flow to the heart and brain, cardiologists view plaque as a good indication for the risk of heart attack and stroke.
The patients who took Niaspan had less plaque in their arteries and also had higher levels of high-density lipoprotein or HDL. Known as “good” cholesterol, HDL is believed to remove cholesterol from the arteries and carry it back to the liver, where it is passes from the body.
The patients who took Zetia had more plaque in their arteries but lower levels of LDL. They also had more heart attacks, strokes and other cardiovascular problems than the patients taking niacin.
If you are on Zetia or Vyotrin please find out more about using niacin as a safe alternative. And if you are worried about LDL cholesterol being some form of evil to be avoided at all costs, please stop back here tomorrow and the days following. I’m going to do my best to explain simply why it’s not evil, why HDL and triglyceride levels are much more important to pay attention to, and why low levels of cholesterol is unsafe at any age but especially midlife and beyond.
Whether you have diabetes or not managing stress is vital to your overall health for so many reasons. In diabetics however it is even more so because stress increases the fight or flight hormones adrenaline and cortisol. One of the many physical responses that occur is an increase in blood sugar levels so we will have the energy to flee or fight the thing that caused the stress in the first place. It worked perfectly in the days of caves and wooly mammoths but can be harmful these days unless we truly are in danger.
In non-diabetic people insulin levels self regulate during times of stress which in turn manages blood sugar levels. In diabetics this system is broken or working below optimal so blood sugar levels rise–just the thing people with diabetes are working to avoid.
“There is a myth out there that it’s all about food as to why the blood sugar rises,” says Richard Hellman, MD, former president of the American Association of Clinical Endocrinologists. The truth is that other factors play a role, he explains, including stress.
First line of defense, know when you are stressed and build in some time to release it. If you have been under long term, chronic stress such as caring for an aging parent or juggling cash and credit to keep your family afloat, your efforts to manage your blood sugar naturally or with insulin and diabetes drugs must be accompanied with a concerted effort to de-stress. If you have never been one to pay attention to stress or finding ways to relax and think it’s for weak of wimpy types, now would be a good time to wise up and pick a relaxation method.
The suggestions are ubiquitous but I’ll list some here: yoga, pilates, Tai Chi, any form of exercise, breathing, meditation, laughter, connecting with people you enjoy, and so on.
And the small daily stressors can add up so why not practice detached observing the next time the line at the grocery store is being held up by the cashier chatting with an elderly shopper? How about laughing off the snarky teenager who had to finish texting before he took your order at the deli counter? All of these things we allow to annoy/stress us are really just plain silly if you think about it.
Take this information to heart–the quality of your life depends on it. Maybe not now, but left unattended, stress–especially for those with diabetes–can rob you of mobility, sight, the use of your limbs, and the ability to live a full, joyful life.
At midlife, we ain’t dead yet and there is still plenty to be do and have; it takes caring for ourselves with a vengeance sometimes but the extra effort sure will be worth it if we can age with the gift of health. порнографиякартинки
